Publication in industry magazines

1. Overcoming CMC challenges in cell and gene therapy: part I – Manufacturing Chemist – Available online
2. Overcoming CMC challenges in cell and gene therapy: part II – Manufacturing Chemist – Available online

First author in 5 peer-reviewed articles

1. 2018, Cancer Res, 78, 1549-60, «A Novel L-Asparaginase with low L-Glutaminase coactivity Is highly efficacious against both T- and B-cell Acute Lymphoblastic Leukemias In Vivo»
2. 2017, J Mol Biol, 429, 3056-74, «Expanding the kinome world: a new family of protein kinase widely conserved in bacteria»
3. 2017, Sci Reports, 7:41643, «The differential ability of asparagine and glutamine in promoting the closed/active enzyme conformation rationalizes the Wolinella succinogenes L-asparaginase substrate specificity»
4. 2016, J Biol Chem, 291, 17664-76, «Design and characterization of Erwinia Chrysanthemi L-Asparaginase variants with diminished L-Glutaminase activity»
5. 2016, Biochemistry, 55, 1246-53, «Structural insight into substrate selectivity of Erwinia chrysanthemi L-asparaginase»

Co-author in 7 peer-reviewed articles

1. 2023, Haematologica, 108, 409-19 «In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia»
2. 2021, Blood Adv, 5, 1963-76 «The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL»
3. 2020, Curr Microbiol, 77, 4063-71, «UbK is Involved in the resistance of Bacillus subtilis to oxidative stress»
4. 2017, Sci Reports, 7:10224, «Discovery of human-like L-asparaginases with potential clinical use by directed evolution»
5. 2015, Oncogenesis 4, e160, «Atlas of Cancer Signaling Network: navigating cancer biology with Google Maps»
6. 2014, J Biol Chem, 289, 33175-86, «Identification and structural analysis of an L-asparaginase enzyme from guinea pig with putative tumor cell-killing properties»
7. 2014, J Med Chem, 57, 9480-94, «Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability»

Inventor in 2 issued patents

1. L-Asparaginase Variants and Fusion Proteins with Reduced L-Glutaminase Activity and Enhanced Stability – Int. Patent. Appl. PCT/US2017/020090 – Google Patents – PDF
2. Truncated Guinea Pig L-Asparaginase Variants and Methods of Use – Int. Patent. Appl. PCT/US2018/046196- Google Patents – PDF